Suppression of inhibitor formation against FVIII in a murine model of hemophilia A by oral delivery of antigens bioencapsulated in plant cells

Hemophilia A is the X-linked bleeding disorder caused by deficiency of coagulation factor VIII (FVIII). To address serious complications of inhibitory antibody formation in current replacement therapy, we created tobacco transplastomic lines expressing FVIII antigens, heavy chain (HC) and C2, fused...

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Hlavní autoři: Sherman, Alexandra, Su, Jin, Lin, Shina, Wang, Xiaomei, Herzog, Roland W., Daniell, Henry
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2014
Témata:
Thrombosis and Hemostasis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4155273/
https://ncbi.nlm.nih.gov/pubmed/24825864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-10-528737
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