Expression and assembly of largest foreign protein in chloroplasts: oral delivery of human FVIII made in lettuce chloroplasts robustly suppresses inhibitor formation in haemophilia A mice

Inhibitor formation is a serious complication of factor VIII (FVIII) replacement therapy for the X‐linked bleeding disorder haemophilia A and occurs in 20%–30% of patients. No prophylactic tolerance protocol currently exists. Although we reported oral tolerance induction using FVIII domains expresse...

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Bibliografske podrobnosti
izdano v:Plant Biotechnol J
Main Authors: Kwon, Kwang‐Chul, Sherman, Alexandra, Chang, Wan‐Jung, Kamesh, Aditya, Biswas, Moanaro, Herzog, Roland W., Daniell, Henry
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2017
Teme:
Research Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5936678/
https://ncbi.nlm.nih.gov/pubmed/29106782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/pbi.12859
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