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Comparisons of the antibody repertoires of a humanized rodent and humans by high throughput sequencing

The humanization of animal model immune systems by genetic engineering has shown great promise for antibody discovery, tolerance studies and for the evaluation of vaccines. Assessment of the baseline antibody repertoires of unimmunized model animals will be useful as a benchmark for future immunizat...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Joyce, Collin, Burton, Dennis R., Briney, Bryan
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6981180/
https://ncbi.nlm.nih.gov/pubmed/31980672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-57764-7
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