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The promise and challenge of high-throughput sequencing of the antibody repertoire

Efforts to determine the antibody repertoire encoded by B cells in the blood or lymphoid organs using high-throughput DNA sequencing technologies have been advancing at an extremely rapid pace and are transforming our understanding of humoral immune responses. Information gained from high-throughput...

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Detalhes bibliográficos
Main Authors: Georgiou, George, Ippolito, Gregory C, Beausang, John, Busse, Christian E, Wardemann, Hedda, Quake, Stephen R
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group US 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4113560/
https://ncbi.nlm.nih.gov/pubmed/24441474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.2782
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