High-throughput sequencing of the paired human immunoglobulin heavy and light chain repertoire

Each B-cell receptor consists of a pair of heavy and light chains. High-throughput sequencing can identify large numbers of heavy- and light-chain variable regions (V(H) and V(L)) in a given B-cell repertoire, but information about endogenous pairing of heavy and light chains is lost after bulk lysi...

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Detalhes bibliográficos
Main Authors: DeKosky, Brandon J, Ippolito, Gregory C, Deschner, Ryan P, Lavinder, Jason J, Wine, Yariv, Rawlings, Brandon M, Varadarajan, Navin, Giesecke, Claudia, Dörner, Thomas, Andrews, Sarah F, Wilson, Patrick C, Hunicke-Smith, Scott P, Willson, C Grant, Ellington, Andrew D, Georgiou, George
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3910347/
https://ncbi.nlm.nih.gov/pubmed/23334449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.2492
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