Single-cell analysis reveals new evolutionary complexity in uveal melanoma

Uveal melanoma (UM) is a highly metastatic cancer that, in contrast to cutaneous melanoma, is largely unresponsive to checkpoint immunotherapy. Here, we interrogate the tumor microenvironment at single-cell resolution using scRNA-seq of 59,915 tumor and non-neoplastic cells from 8 primary and 3 meta...

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Udgivet i:Nat Commun
Main Authors: Durante, Michael A., Rodriguez, Daniel A., Kurtenbach, Stefan, Kuznetsov, Jeffim N., Sanchez, Margaret I., Decatur, Christina L., Snyder, Helen, Feun, Lynn G., Livingstone, Alan S., Harbour, J. William
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6981133/
https://ncbi.nlm.nih.gov/pubmed/31980621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14256-1
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