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BAP1 loss is associated with DNA methylomic repatterning in highly aggressive Class 2 uveal melanomas
PURPOSE: The strong association between BAP1 mutations and metastasizing Class 2 uveal melanoma (UM) suggests that epigenetic alterations may play a significant role in tumor progression. Thus, we characterized the impact of BAP1 loss on the DNA methylome in UM. EXPERIMENTAL DESIGN: Global DNA methy...
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| Publicado no: | Clin Cancer Res |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6744995/ https://ncbi.nlm.nih.gov/pubmed/31285370 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-0366 |
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