BAP1 loss is associated with DNA methylomic repatterning in highly aggressive Class 2 uveal melanomas

PURPOSE: The strong association between BAP1 mutations and metastasizing Class 2 uveal melanoma (UM) suggests that epigenetic alterations may play a significant role in tumor progression. Thus, we characterized the impact of BAP1 loss on the DNA methylome in UM. EXPERIMENTAL DESIGN: Global DNA methy...

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Udgivet i:Clin Cancer Res
Main Authors: Field, Matthew G., Kuznetsov, Jeffim N., Bussies, Parker L., Cai, Louie, Alawa, Karam A., Decatur, Christina L., Kurtenbach, Stefan, Harbour, J. William
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744995/
https://ncbi.nlm.nih.gov/pubmed/31285370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-0366
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