Epigenetic reprogramming and aberrant expression of PRAME are associated with increased metastatic risk in Class 1 and Class 2 uveal melanomas

BACKGROUND: We previously identified PRAME as a biomarker for metastatic risk in Class 1 uveal melanomas. In this study, we sought to define a threshold value for positive PRAME expression (PRAME+) in a large dataset, identify factors associated with PRAME expression, evaluate the prognostic value o...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Field, Matthew G., Durante, Michael A., Decatur, Christina L., Tarlan, Bercin, Oelschlager, Kristen M., Stone, John F., Kuznetsov, Jeffim, Bowcock, Anne M., Kurtenbach, Stefan, Harbour, J. William
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5312306/
https://ncbi.nlm.nih.gov/pubmed/27486988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10962
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