Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and - independent cellular responses in Alzheimer’s disease

Glia have been implicated in Alzheimer’s disease (AD) pathogenesis. Variants of the microglia receptor TREM2 increase AD risk and activation of “disease-associated microglia” (DAM) is dependent on TREM2 in mouse models of AD. We surveyed gene expression changes associated with AD pathology and TREM2...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Nat Med
Autors principals: Zhou, Yingyue, Song, Wilbur M., Andhey, Prabhakar S., Swain, Amanda, Levy, Tyler, Miller, Kelly R., Poliani, Pietro L., Cominelli, Manuela, Grover, Shikha, Gilfillan, Susan, Cella, Marina, Ulland, Tyler K., Zaitsev, Konstantin, Miyashita, Akinori, Ikeuchi, Takeshi, Sainouchi, Makoto, Kakita, Akiyoshi, Bennett, David A., Schneider, Julie A., Nichols, Michael R., Beausoleil, Sean A., Ulrich, Jason, Holtzman, David M., Artyomov, Maxim N., Colonna, Marco
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6980793/
https://ncbi.nlm.nih.gov/pubmed/31932797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-019-0695-9
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars