Загрузка...
Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation
INTRODUCTION: TREM2 is a lipid-sensing activating receptor on microglia known to be important for Alzheimer's disease (AD), but whether it plays a beneficial or detrimental role in disease pathogenesis is controversial. METHODS: We analyzed AD risk of TREM2 variants in the NIMH AD Genetics Init...
Сохранить в:
| Опубликовано в: : | Alzheimers Dement |
|---|---|
| Главные авторы: | , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2016
|
| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5299056/ https://ncbi.nlm.nih.gov/pubmed/27520774 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jalz.2016.07.004 |
| Метки: |
Добавить метку
Нет меток, Требуется 1-ая метка записи!
|