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Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation
INTRODUCTION: TREM2 is a lipid-sensing activating receptor on microglia known to be important for Alzheimer's disease (AD), but whether it plays a beneficial or detrimental role in disease pathogenesis is controversial. METHODS: We analyzed AD risk of TREM2 variants in the NIMH AD Genetics Init...
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| Udgivet i: | Alzheimers Dement |
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| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5299056/ https://ncbi.nlm.nih.gov/pubmed/27520774 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jalz.2016.07.004 |
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