Alzheimer's disease-associated TREM2 variants exhibit either decreased or increased ligand-dependent activation

INTRODUCTION: TREM2 is a lipid-sensing activating receptor on microglia known to be important for Alzheimer's disease (AD), but whether it plays a beneficial or detrimental role in disease pathogenesis is controversial. METHODS: We analyzed AD risk of TREM2 variants in the NIMH AD Genetics Init...

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Udgivet i:Alzheimers Dement
Main Authors: Song, Wilbur, Hooli, Basavaraj, Mullin, Kristina, Jin, Sheng Chih, Cella, Marina, Ulland, Tyler K., Wang, Yaming, Tanzi, Rudolph, Colonna, Marco
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5299056/
https://ncbi.nlm.nih.gov/pubmed/27520774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jalz.2016.07.004
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