The rare TREM2 R47H variant exerts only a modest effect on Alzheimer disease risk

OBJECTIVES: Recently, 2 independent studies reported that a rare missense variant, rs75932628 (R47H), in exon 2 of the gene encoding the “triggering receptor expressed on myeloid cells 2” (TREM2) significantly increases the risk of Alzheimer disease (AD) with an effect size comparable to that of the...

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Main Authors: Hooli, Basavaraj V., Parrado, Antonio R., Mullin, Kristina, Yip, Wai-Ki, Liu, Tian, Roehr, Johannes T., Qiao, Dandi, Jessen, Frank, Peters, Oliver, Becker, Tim, Ramirez, Alfredo, Lange, Christoph, Bertram, Lars, Tanzi, Rudolph E.
Format: Artigo
Jezik:Inglês
Izdano: Lippincott Williams & Wilkins 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4189101/
https://ncbi.nlm.nih.gov/pubmed/25186855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000000855
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