Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake

p62/SQSTM1 is an autophagy receptor and signaling adaptor with an N-terminal PB1 domain that forms the scaffold of phase-separated p62 bodies in the cell. The molecular determinants that govern PB1 domain filament formation in vitro remain to be determined and the role of p62 filaments inside the ce...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Jakobi, Arjen J., Huber, Stefan T., Mortensen, Simon A., Schultz, Sebastian W., Palara, Anthimi, Kuhm, Tanja, Shrestha, Birendra Kumar, Lamark, Trond, Hagen, Wim J. H., Wilmanns, Matthias, Johansen, Terje, Brech, Andreas, Sachse, Carsten
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2020
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6978347/
https://ncbi.nlm.nih.gov/pubmed/31974402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14343-8
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