BCG revaccination boosts adaptive polyfunctional Th1/Th17 and innate effectors in IGRA(+) and IGRA(–) Indian adults

BACKGROUND: Bacille Calmette-Guérin (BCG) vaccine is protective against Tuberculosis (TB) in children, but its efficacy wanes with age. Consequently, determining if BCG revaccination augments anti-TB immunity in young adults in TB endemic regions is vital. METHODS: Two hundred healthy adults, BCG va...

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Bibliographische Detailangaben
Veröffentlicht in:JCI Insight
Hauptverfasser: Rakshit, Srabanti, Ahmed, Asma, Adiga, Vasista, Sundararaj, Bharath K., Sahoo, Pravat Nalini, Kenneth, John, D’Souza, George, Bonam, Wesley, Johnson, Christina, Franken, Kees L.M.C., Ottenhoff, Tom H.M., Finak, Greg, Gottardo, Raphael, Stuart, Kenneth D., De Rosa, Stephen C., McElrath, M. Juliana, Vyakarnam, Annapurna
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2019
Schlagworte:
Clinical Medicine
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6975271/
https://ncbi.nlm.nih.gov/pubmed/31743110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.130540
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