BCG revaccination boosts adaptive polyfunctional Th1/Th17 and innate effectors in IGRA(+) and IGRA(–) Indian adults

BACKGROUND: Bacille Calmette-Guérin (BCG) vaccine is protective against Tuberculosis (TB) in children, but its efficacy wanes with age. Consequently, determining if BCG revaccination augments anti-TB immunity in young adults in TB endemic regions is vital. METHODS: Two hundred healthy adults, BCG va...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Rakshit, Srabanti, Ahmed, Asma, Adiga, Vasista, Sundararaj, Bharath K., Sahoo, Pravat Nalini, Kenneth, John, D’Souza, George, Bonam, Wesley, Johnson, Christina, Franken, Kees L.M.C., Ottenhoff, Tom H.M., Finak, Greg, Gottardo, Raphael, Stuart, Kenneth D., De Rosa, Stephen C., McElrath, M. Juliana, Vyakarnam, Annapurna
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Clinical Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6975271/
https://ncbi.nlm.nih.gov/pubmed/31743110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.130540
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