BCG revaccination boosts adaptive polyfunctional Th1/Th17 and innate effectors in IGRA(+) and IGRA(–) Indian adults

BACKGROUND: Bacille Calmette-Guérin (BCG) vaccine is protective against Tuberculosis (TB) in children, but its efficacy wanes with age. Consequently, determining if BCG revaccination augments anti-TB immunity in young adults in TB endemic regions is vital. METHODS: Two hundred healthy adults, BCG va...

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Publicado en:JCI Insight
Autores principales: Rakshit, Srabanti, Ahmed, Asma, Adiga, Vasista, Sundararaj, Bharath K., Sahoo, Pravat Nalini, Kenneth, John, D’Souza, George, Bonam, Wesley, Johnson, Christina, Franken, Kees L.M.C., Ottenhoff, Tom H.M., Finak, Greg, Gottardo, Raphael, Stuart, Kenneth D., De Rosa, Stephen C., McElrath, M. Juliana, Vyakarnam, Annapurna
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2019
Materias:
Clinical Medicine
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6975271/
https://ncbi.nlm.nih.gov/pubmed/31743110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.130540
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