Pulsed glucocorticoids enhance dystrophic muscle performance through epigenetic-metabolic reprogramming

In humans, chronic glucocorticoid use is associated with side effects like muscle wasting, obesity, and metabolic syndrome. Intermittent steroid dosing has been proposed in Duchenne Muscular Dystrophy patients to mitigate the side effects seen with daily steroid intake. We evaluated biomarkers from...

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Publicado en:JCI Insight
Autores principales: Quattrocelli, Mattia, Zelikovich, Aaron S., Jiang, Zhen, Peek, Clara Bien, Demonbreun, Alexis R., Kuntz, Nancy L., Barish, Grant D., Haldar, Saptarsi M., Bass, Joseph, McNally, Elizabeth M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2019
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6975267/
https://ncbi.nlm.nih.gov/pubmed/31852847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.132402
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