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Pulsed glucocorticoids enhance dystrophic muscle performance through epigenetic-metabolic reprogramming

In humans, chronic glucocorticoid use is associated with side effects like muscle wasting, obesity, and metabolic syndrome. Intermittent steroid dosing has been proposed in Duchenne Muscular Dystrophy patients to mitigate the side effects seen with daily steroid intake. We evaluated biomarkers from...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Quattrocelli, Mattia, Zelikovich, Aaron S., Jiang, Zhen, Peek, Clara Bien, Demonbreun, Alexis R., Kuntz, Nancy L., Barish, Grant D., Haldar, Saptarsi M., Bass, Joseph, McNally, Elizabeth M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6975267/
https://ncbi.nlm.nih.gov/pubmed/31852847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.132402
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