Pulsed glucocorticoids enhance dystrophic muscle performance through epigenetic-metabolic reprogramming

In humans, chronic glucocorticoid use is associated with side effects like muscle wasting, obesity, and metabolic syndrome. Intermittent steroid dosing has been proposed in Duchenne Muscular Dystrophy patients to mitigate the side effects seen with daily steroid intake. We evaluated biomarkers from...

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Bibliographic Details
Published in:JCI Insight
Main Authors: Quattrocelli, Mattia, Zelikovich, Aaron S., Jiang, Zhen, Peek, Clara Bien, Demonbreun, Alexis R., Kuntz, Nancy L., Barish, Grant D., Haldar, Saptarsi M., Bass, Joseph, McNally, Elizabeth M.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6975267/
https://ncbi.nlm.nih.gov/pubmed/31852847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.132402
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