PET imaging of mGluR5 in Alzheimer’s disease

BACKGROUND: Metabotropic glutamate subtype 5 receptors (mGluR5) modulate synaptic transmission and may constitute an important therapeutic target in Alzheimer’s disease (AD) by mediating the synaptotoxic action of amyloid-β oligomers. We utilized the positron emission tomography (PET) radioligand [(...

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發表在:Alzheimers Res Ther
Main Authors: Mecca, Adam P., McDonald, Julia W., Michalak, Hannah R., Godek, Tyler A., Harris, Joanna E., Pugh, Erika A., Kemp, Emily C., Chen, Ming-Kai, Salardini, Arash, Nabulsi, Nabeel B., Lim, Keunpoong, Huang, Yiyun, Carson, Richard E., Strittmatter, Stephen M., van Dyck, Christopher H.
格式: Artigo
語言:Inglês
出版: BioMed Central 2020
主題:
Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6969979/
https://ncbi.nlm.nih.gov/pubmed/31954399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-020-0582-0
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