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Proteome-wide observation of the phenomenon of life on the edge of solubility

To function effectively proteins must avoid aberrant aggregation, and hence they are expected to be expressed at concentrations safely below their solubility limits. By analyzing proteome-wide mass spectrometry data of Caenorhabditis elegans, however, we show that the levels of about three-quarters...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Vecchi, Giulia, Sormanni, Pietro, Mannini, Benedetta, Vandelli, Andrea, Tartaglia, Gian Gaetano, Dobson, Christopher M., Hartl, F. Ulrich, Vendruscolo, Michele
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2020
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6969518/
https://ncbi.nlm.nih.gov/pubmed/31892536
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1910444117
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