MUC1-C regulates lineage plasticity driving progression to neuroendocrine prostate cancer

Neuroendocrine prostate cancer (NEPC) is an aggressive malignancy with no effective targeted therapies. The oncogenic MUC1-C protein is overexpressed in castration-resistant prostate cancer (CRPC) and NEPC, but its specific role is unknown. Here, we demonstrate that upregulation of MUC1-C in androge...

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Опубликовано в: :Nat Commun
Главные авторы: Yasumizu, Yota, Rajabi, Hasan, Jin, Caining, Hata, Tsuyoshi, Pitroda, Sean, Long, Mark D., Hagiwara, Masayuki, Li, Wei, Hu, Qiang, Liu, Song, Yamashita, Nami, Fushimi, Atsushi, Kui, Ling, Samur, Mehmet, Yamamoto, Masaaki, Zhang, Yan, Zhang, Ning, Hong, Deli, Maeda, Takahiro, Kosaka, Takeo, Wong, Kwok K., Oya, Mototsugu, Kufe, Donald
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2020
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6969104/
https://ncbi.nlm.nih.gov/pubmed/31953400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14219-6
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