MUC1-C ACTIVATES THE NuRD COMPLEX TO DRIVE DEDIFFERENTIATION OF TRIPLE-NEGATIVE BREAST CANCER CELLS

The NuRD chromatin remodeling and deacetylation complex, which includes MTA1, MBD3, CHD4 and HDAC1 among other components, is of importance for development and cancer progression. The oncogenic MUC1-C protein activates EZH2 and BMI1 in the epigenetic reprogramming of triple-negative breast cancer (T...

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Publicado no:Cancer Res
Main Authors: Hata, Tsuyoshi, Rajabi, Hasan, Takahashi, Hidekazu, Yasumizu, Yota, Li, Wei, Jin, Caining, Long, Mark D., Hu, Qiang, Liu, Song, Fushimi, Atsushi, Yamashita, Nami, Kui, Ling, Hong, Deli, Yamamoto, Masaaki, Miyo, Masaaki, Hiraki, Masayuki, Maeda, Takahiro, Suzuki, Yozo, Samur, Mehmet K., Kufe, Donald
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6881519/
https://ncbi.nlm.nih.gov/pubmed/31519689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-1034
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