MUC1-C regulates lineage plasticity driving progression to neuroendocrine prostate cancer

Neuroendocrine prostate cancer (NEPC) is an aggressive malignancy with no effective targeted therapies. The oncogenic MUC1-C protein is overexpressed in castration-resistant prostate cancer (CRPC) and NEPC, but its specific role is unknown. Here, we demonstrate that upregulation of MUC1-C in androge...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Yasumizu, Yota, Rajabi, Hasan, Jin, Caining, Hata, Tsuyoshi, Pitroda, Sean, Long, Mark D., Hagiwara, Masayuki, Li, Wei, Hu, Qiang, Liu, Song, Yamashita, Nami, Fushimi, Atsushi, Kui, Ling, Samur, Mehmet, Yamamoto, Masaaki, Zhang, Yan, Zhang, Ning, Hong, Deli, Maeda, Takahiro, Kosaka, Takeo, Wong, Kwok K., Oya, Mototsugu, Kufe, Donald
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6969104/
https://ncbi.nlm.nih.gov/pubmed/31953400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14219-6
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