Impact of anticancer chemotherapy on the extension of beta-lactamase spectrum: an example with KPC-type carbapenemase activity towards ceftazidime-avibactam

Through their action on DNA replication, anticancer chemotherapies could increase the basal mutation rate in bacteria and increase the risk of selecting antibiotic resistant mutants. We investigated the impact of several drugs on a beta-lactamase model using KPC-type carbapenemase-producing Enteroba...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Hobson, Claire Amaris, Bonacorsi, Stéphane, Hocquet, Didier, Baruchel, André, Fahd, Mony, Storme, Thomas, Tang, Raksamy, Doit, Catherine, Tenaillon, Olivier, Birgy, André
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6969056/
https://ncbi.nlm.nih.gov/pubmed/31953453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-57505-w
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