KPC-50 Confers Resistance to Ceftazidime-Avibactam Associated with Reduced Carbapenemase Activity

KPC-50 is a KPC-3 variant identified from a Klebsiella pneumoniae clinical isolate recovered in Switzerland in 2019. Compared to KPC-3, KPC-50 shows (i) a three-amino-acid insertion (Glu-Ala-Val) between amino acids 276 and 277, (ii) an increased affinity to ceftazidime, (iii) a decreased sensitivit...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Poirel, Laurent, Vuillemin, Xavier, Juhas, Mario, Masseron, Amandine, Bechtel-Grosch, Ursina, Tiziani, Simon, Mancini, Stefano, Nordmann, Patrice
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2020
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7526841/
https://ncbi.nlm.nih.gov/pubmed/32457107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00321-20
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