Impact of anticancer chemotherapy on the extension of beta-lactamase spectrum: an example with KPC-type carbapenemase activity towards ceftazidime-avibactam

Through their action on DNA replication, anticancer chemotherapies could increase the basal mutation rate in bacteria and increase the risk of selecting antibiotic resistant mutants. We investigated the impact of several drugs on a beta-lactamase model using KPC-type carbapenemase-producing Enteroba...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Hobson, Claire Amaris, Bonacorsi, Stéphane, Hocquet, Didier, Baruchel, André, Fahd, Mony, Storme, Thomas, Tang, Raksamy, Doit, Catherine, Tenaillon, Olivier, Birgy, André
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6969056/
https://ncbi.nlm.nih.gov/pubmed/31953453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-57505-w
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