Implementing Patient-Derived Xenografts to Assess the Effectiveness of Cyclin-Dependent Kinase Inhibitors in Glioblastoma

Glioblastoma (GBM) is the most common primary brain tumor with no available cure. As previously described, seliciclib, a first-generation cyclin-dependent kinase (CDK) inhibitor, down-regulates the anti-apoptotic protein, Mcl-1, in GBM, thereby sensitizing GBM cells to the apoptosis-inducing effects...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Noonan, Janis J., Jarzabek, Monika, Lincoln, Frank A., Cavanagh, Brenton L., Pariag, Arhona R., Juric, Viktorija, Young, Leonie S., Ligon, Keith L., Jahns, Hanne, Zheleva, Daniella, Prehn, Jochen H. M., Rehm, Markus, Byrne, Annette T., Murphy, Brona M.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6966586/
https://ncbi.nlm.nih.gov/pubmed/31842413
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11122005
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