Transcriptional CDK Inhibitors CYC065 and THZ1 Induce Apoptosis in Glioma Stem Cells Derived from Recurrent GBM

Glioma stem cells (GSCs) are tumour initiating cells which contribute to treatment resistance, temozolomide (TMZ) chemotherapy and radiotherapy, in glioblastoma (GBM), the most aggressive adult brain tumour. A major contributor to the uncontrolled tumour cell proliferation in GBM is the hyper activa...

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Pubblicato in:Cells
Autori principali: Juric, Viktorija, Düssmann, Heiko, Lamfers, Martine L. M., Prehn, Jochen H. M., Rehm, Markus, Murphy, Brona M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8151379/
https://ncbi.nlm.nih.gov/pubmed/34066147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells10051182
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