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Fadraciclib (CYC065), a novel CDK inhibitor, targets key pro-survival and oncogenic pathways in cancer

Cyclin-dependent kinases (CDKs) contribute to the cancer hallmarks of uncontrolled proliferation and increased survival. As a result, over the last two decades substantial efforts have been directed towards identification and development of pharmaceutical CDK inhibitors. Insights into the biological...

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Detalles Bibliográficos
Publicado en:PLoS One
Main Authors: Frame, Sheelagh, Saladino, Chiara, MacKay, Craig, Atrash, Butrus, Sheldrake, Peter, McDonald, Edward, Clarke, Paul A., Workman, Paul, Blake, David, Zheleva, Daniella
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7347136/
https://ncbi.nlm.nih.gov/pubmed/32645016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0234103
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