The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction

Optimal functioning of neuronal networks is critical to the complex cognitive processes of memory and executive function that deteriorate in Alzheimer’s disease (AD). Here we use cellular and animal models as well as human biospecimens to show that AD-related stressors mediate global disturbances in...

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出版年:Nat Commun
主要な著者: Inda, Maria Carmen, Joshi, Suhasini, Wang, Tai, Bolaender, Alexander, Gandu, Srinivasa, Koren III, John, Che, Alicia Yue, Taldone, Tony, Yan, Pengrong, Sun, Weilin, Uddin, Mohammad, Panchal, Palak, Riolo, Matthew, Shah, Smit, Barlas, Afsar, Xu, Ke, Chan, Lon Yin L., Gruzinova, Alexandra, Kishinevsky, Sarah, Studer, Lorenz, Fossati, Valentina, Noggle, Scott A., White, Julie R., de Stanchina, Elisa, Sequeira, Sonia, Anthoney, Kyle H., Steele, John W., Manova-Todorova, Katia, Patil, Sujata, Dunphy, Mark P., Pillarsetty, NagaVaraKishore, Pereira, Ana C., Erdjument-Bromage, Hediye, Neubert, Thomas A., Rodina, Anna, Ginsberg, Stephen D., De Marco Garcia, Natalia, Luo, Wenjie, Chiosis, Gabriela
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2020
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6965647/
https://ncbi.nlm.nih.gov/pubmed/31949159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14082-5
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