The epichaperome is a mediator of toxic hippocampal stress and leads to protein connectivity-based dysfunction

Optimal functioning of neuronal networks is critical to the complex cognitive processes of memory and executive function that deteriorate in Alzheimer’s disease (AD). Here we use cellular and animal models as well as human biospecimens to show that AD-related stressors mediate global disturbances in...

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Publicado no:Nat Commun
Main Authors: Inda, Maria Carmen, Joshi, Suhasini, Wang, Tai, Bolaender, Alexander, Gandu, Srinivasa, Koren III, John, Che, Alicia Yue, Taldone, Tony, Yan, Pengrong, Sun, Weilin, Uddin, Mohammad, Panchal, Palak, Riolo, Matthew, Shah, Smit, Barlas, Afsar, Xu, Ke, Chan, Lon Yin L., Gruzinova, Alexandra, Kishinevsky, Sarah, Studer, Lorenz, Fossati, Valentina, Noggle, Scott A., White, Julie R., de Stanchina, Elisa, Sequeira, Sonia, Anthoney, Kyle H., Steele, John W., Manova-Todorova, Katia, Patil, Sujata, Dunphy, Mark P., Pillarsetty, NagaVaraKishore, Pereira, Ana C., Erdjument-Bromage, Hediye, Neubert, Thomas A., Rodina, Anna, Ginsberg, Stephen D., De Marco Garcia, Natalia, Luo, Wenjie, Chiosis, Gabriela
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6965647/
https://ncbi.nlm.nih.gov/pubmed/31949159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14082-5
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