Amplification and overexpression of E2 ubiquitin conjugase UBE2T promotes homologous recombination in multiple myeloma

UBE2T is frequently amplified and/or overexpressed and is required for homologous recombination activity in multiple myeloma cells. UBE2T is a potential therapeutic target to increase chemosensitivity in multiple myeloma cells.

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Bibliografiske detaljer
Udgivet i:Blood Adv
Main Authors: Alagpulinsa, David A., Kumar, Subodh, Talluri, Srikanth, Nanjappa, Purushothama, Buon, Leutz, Chakraborty, Chandraditya, Samur, Mehmet K., Szalat, Raphael, Shammas, Masood A., Munshi, Nikhil C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2019
Fag:
Stimulus Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6963244/
https://ncbi.nlm.nih.gov/pubmed/31805191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000181
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