Role of apurinic/apyrimidinic nucleases in the regulation of homologous recombination in myeloma: mechanisms and translational significance

We have previously reported that homologous recombination (HR) is dysregulated in multiple myeloma (MM) and contributes to genomic instability and development of drug resistance. We now demonstrate that base excision repair (BER) associated apurinic/apyrimidinic (AP) nucleases (APEX1 and APEX2) cont...

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Pubblicato in:Blood Cancer J
Autori principali: Kumar, Subodh, Talluri, Srikanth, Pal, Jagannath, Yuan, Xiaoli, Lu, Renquan, Nanjappa, Puru, Samur, Mehmet K., Munshi, Nikhil C., Shammas, Masood A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6177467/
https://ncbi.nlm.nih.gov/pubmed/30301882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41408-018-0129-9
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