Role of apurinic/apyrimidinic nucleases in the regulation of homologous recombination in myeloma: mechanisms and translational significance

We have previously reported that homologous recombination (HR) is dysregulated in multiple myeloma (MM) and contributes to genomic instability and development of drug resistance. We now demonstrate that base excision repair (BER) associated apurinic/apyrimidinic (AP) nucleases (APEX1 and APEX2) cont...

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Detalhes bibliográficos
Publicado no:Blood Cancer J
Main Authors: Kumar, Subodh, Talluri, Srikanth, Pal, Jagannath, Yuan, Xiaoli, Lu, Renquan, Nanjappa, Puru, Samur, Mehmet K., Munshi, Nikhil C., Shammas, Masood A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6177467/
https://ncbi.nlm.nih.gov/pubmed/30301882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41408-018-0129-9
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