Targeting homologous recombination and telomerase in Barrett’s adenocarcinoma: Impact on telomere maintenance, genomic instability, and tumor growth

Homologous recombination (HR), a mechanism to accurately repair DNA in normal cells, is deregulated in cancer. Elevated/deregulated HR is implicated in genomic instability and telomere maintenance, which are critical lifelines of cancer cells. We have previously shown that HR activity is elevated an...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Lu, Renquan, Pal, Jagannath, Buon, Leutz, Nanjappa, Puru, Shi, Jialan, Fulciniti, Mariateresa, Tai, Yu-Tzu, Guo, Lin, Yu, Min, Gryaznov, Sergei, Munshi, Nikhil C., Shammas, Masood A.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2013
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3940666/
https://ncbi.nlm.nih.gov/pubmed/23604115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.103
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