Targeting homologous recombination and telomerase in Barrett’s adenocarcinoma: Impact on telomere maintenance, genomic instability, and tumor growth

Homologous recombination (HR), a mechanism to accurately repair DNA in normal cells, is deregulated in cancer. Elevated/deregulated HR is implicated in genomic instability and telomere maintenance, which are critical lifelines of cancer cells. We have previously shown that HR activity is elevated an...

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Hauptverfasser: Lu, Renquan, Pal, Jagannath, Buon, Leutz, Nanjappa, Puru, Shi, Jialan, Fulciniti, Mariateresa, Tai, Yu-Tzu, Guo, Lin, Yu, Min, Gryaznov, Sergei, Munshi, Nikhil C., Shammas, Masood A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3940666/
https://ncbi.nlm.nih.gov/pubmed/23604115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2013.103
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