Grp78 Loss in Epithelial Progenitors Reveals an Age-linked Role for Endoplasmic Reticulum Stress in Pulmonary Fibrosis

Rationale: Alveolar epithelial cell (AEC) injury and dysregulated repair are implicated in the pathogenesis of pulmonary fibrosis. Endoplasmic reticulum (ER) stress in AEC has been observed in idiopathic pulmonary fibrosis (IPF), a disease of aging. Objectives: To investigate a causal role for ER st...

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Detalhes bibliográficos
Publicado no:Am J Respir Crit Care Med
Main Authors: Borok, Zea, Horie, Masafumi, Flodby, Per, Wang, Hongjun, Liu, Yixin, Ganesh, Sivagini, Firth, Amy L., Minoo, Parviz, Li, Changgong, Beers, Michael F., Lee, Amy S., Zhou, Beiyun
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2020
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6961744/
https://ncbi.nlm.nih.gov/pubmed/31738079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201902-0451OC
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