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Beyond the endoplasmic reticulum: atypical GRP78 in cell viability, signaling and therapeutic targeting
GRP78 is traditionally regarded as a major endoplasmic reticulum (ER) chaperone facilitating protein folding and assembly, protein quality control, Ca(2+) binding and regulating ER stress signaling. It is a potent anti-apoptotic protein and plays a critical role in tumor cell survival, tumor progres...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2011
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3353658/ https://ncbi.nlm.nih.gov/pubmed/21309747 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20101569 |
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