The 78-kD Glucose-Regulated Protein Regulates Endoplasmic Reticulum Homeostasis and Distal Epithelial Cell Survival during Lung Development

Bronchopulmonary dysplasia (BPD), a chronic lung disease of prematurity, has been linked to endoplasmic reticulum (ER) stress. To investigate a causal role for ER stress in BPD pathogenesis, we generated conditional knockout (KO) mice (cGrp78(f/f)) with lung epithelial cell–specific KO of Grp78, a g...

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Detalhes bibliográficos
Publicado no:Am J Respir Cell Mol Biol
Main Authors: Flodby, Per, Li, Changgong, Liu, Yixin, Wang, Hongjun, Marconett, Crystal N., Laird-Offringa, Ite A., Minoo, Parviz, Lee, Amy S., Zhou, Beiyun
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4942208/
https://ncbi.nlm.nih.gov/pubmed/26816051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2015-0327OC
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