Targeting the orphan nuclear receptor NR2F6 in T cells primes tumors for immune checkpoint therapy

BACKGROUND: NR2F6 has been proposed as an alternative cancer immune checkpoint in the effector T cell compartment. However, a realistic assessment of the in vivo therapeutic potential of NR2F6 requires acute depletion. METHODS: Employing primary T cells isolated from Cas9-transgenic mice for electro...

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Bibliographic Details
Published in:Cell Commun Signal
Main Authors: Klepsch, Victoria, Pommermayr, Maria, Humer, Dominik, Brigo, Natascha, Hermann-Kleiter, Natascha, Baier, Gottfried
Format: Artigo
Language:Inglês
Published: BioMed Central 2020
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6961368/
https://ncbi.nlm.nih.gov/pubmed/31937317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-019-0454-z
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