Orphan Nuclear Receptor NR2F6 Suppresses T Follicular Helper Cell Accumulation through Regulation of IL-21

CD4 T follicular helper (Tfh) cells are specialized in helping B cells during the germinal center (GC) reaction and ultimately promote long-term humoral immunity. Here we report that loss of the nuclear orphan receptor NR2F6 causes enhanced survival and accumulation of Tfh cells, GC B cells, and pla...

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Détails bibliographiques
Publié dans:Cell Rep
Auteurs principaux: Olson, William J., Jakic, Bojana, Labi, Verena, Schoeler, Katia, Kind, Michaela, Klepsch, Victoria, Baier, Gottfried, Hermann-Kleiter, Natascha
Format: Artigo
Langue:Inglês
Publié: Cell Press 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6791812/
https://ncbi.nlm.nih.gov/pubmed/31509749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.08.024
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