The Nuclear Orphan Receptor NR2F6 Suppresses Lymphocyte Activation and T Helper 17-Dependent Autoimmunity

The protein kinase C (PKC) family of serine-threonine kinases plays a central role in T lymphocyte activation. Here, we identify NR2F6, a nuclear zinc-finger orphan receptor, as a critical PKC substrate and essential regulator of CD4(+) T cell activation responses. NR2F6 potently antagonized the abi...

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Détails bibliographiques
Publié dans:Immunity
Auteurs principaux: Hermann-Kleiter, Natascha, Gruber, Thomas, Lutz-Nicoladoni, Christina, Thuille, Nikolaus, Fresser, Friedrich, Labi, Verena, Schiefermeier, Natalia, Warnecke, Marei, Huber, Lukas, Villunger, Andreas, Eichele, Gregor, Kaminski, Sandra, Baier, Gottfried
Format: Artigo
Langue:Inglês
Publié: 2008
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4941926/
https://ncbi.nlm.nih.gov/pubmed/18701084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2008.06.008
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