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Nuclear orphan receptor NR2F6 directly antagonizes NFAT and RORγt binding to the Il17a promoter

Interleukin-17A (IL-17A) is the signature cytokine produced by Th17 CD4(+) T cells and has been tightly linked to autoimmune pathogenesis. In particular, the transcription factors NFAT and RORγt are known to activate Il17a transcription, although the detailed mechanism of action remains incompletely...

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書誌詳細
主要な著者: Hermann-Kleiter, Natascha, Meisel, Marlies, Fresser, Friedrich, Thuille, Nikolaus, Müller, Mathias, Roth, Lukas, Katopodis, Andreas, Baier, Gottfried
フォーマット: Artigo
言語:Inglês
出版事項: Academic Press 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516707/
https://ncbi.nlm.nih.gov/pubmed/22921335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2012.07.007
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