Nuclear orphan receptor NR2F6 directly antagonizes NFAT and RORγt binding to the Il17a promoter

Interleukin-17A (IL-17A) is the signature cytokine produced by Th17 CD4(+) T cells and has been tightly linked to autoimmune pathogenesis. In particular, the transcription factors NFAT and RORγt are known to activate Il17a transcription, although the detailed mechanism of action remains incompletely...

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Bibliographische Detailangaben
Hauptverfasser: Hermann-Kleiter, Natascha, Meisel, Marlies, Fresser, Friedrich, Thuille, Nikolaus, Müller, Mathias, Roth, Lukas, Katopodis, Andreas, Baier, Gottfried
Format: Artigo
Sprache:Inglês
Veröffentlicht: Academic Press 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516707/
https://ncbi.nlm.nih.gov/pubmed/22921335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2012.07.007
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