The Nuclear Orphan Receptor NR2F6 Is a Central Checkpoint for Cancer Immune Surveillance

Nuclear receptor subfamily 2, group F, member 6 (NR2F6) is an orphan member of the nuclear receptor superfamily. Here, we show that genetic ablation of Nr2f6 significantly improves survival in the murine transgenic TRAMP prostate cancer model. Furthermore, Nr2f6(−/−) mice spontaneously reject implan...

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發表在:Cell Rep
Main Authors: Hermann-Kleiter, Natascha, Klepsch, Victoria, Wallner, Stephanie, Siegmund, Kerstin, Klepsch, Sebastian, Tuzlak, Selma, Villunger, Andreas, Kaminski, Sandra, Pfeifhofer-Obermair, Christa, Gruber, Thomas, Wolf, Dominik, Baier, Gottfried
格式: Artigo
語言:Inglês
出版: Cell Press 2015
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4594157/
https://ncbi.nlm.nih.gov/pubmed/26387951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.08.035
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