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Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors
The carboxylesterase Notum is a key negative regulator of the Wnt signaling pathway by mediating the depalmitoleoylation of Wnt proteins. Our objective was to discover potent small molecule inhibitors of Notum suitable for exploring the regulation of Wnt signaling in the central nervous system. Scaf...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier Science Ltd
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6961116/ https://ncbi.nlm.nih.gov/pubmed/31862412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.126751 |
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