Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors

The carboxylesterase Notum is a key negative regulator of the Wnt signaling pathway by mediating the depalmitoleoylation of Wnt proteins. Our objective was to discover potent small molecule inhibitors of Notum suitable for exploring the regulation of Wnt signaling in the central nervous system. Scaf...

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Veröffentlicht in:Bioorg Med Chem Lett
Hauptverfasser: Atkinson, Benjamin N., Steadman, David, Mahy, William, Zhao, Yuguang, Sipthorp, James, Bayle, Elliott D., Svensson, Fredrik, Papageorgiou, George, Jeganathan, Fiona, Frew, Sarah, Monaghan, Amy, Bictash, Magda, Jones, E. Yvonne, Fish, Paul V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier Science Ltd 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6961116/
https://ncbi.nlm.nih.gov/pubmed/31862412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.126751
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