GRK6 regulates the hemostatic response to injury through its rate-limiting effects on GPCR signaling in platelets

G protein–coupled receptors (GPCRs) mediate the majority of platelet activation in response to agonists. However, questions remain regarding the mechanisms that provide negative feedback toward activated GPCRs to limit platelet activation and thrombus formation. Here we provide the first evidence th...

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Détails bibliographiques
Publié dans:Blood Adv
Auteurs principaux: Chen, Xi, Gupta, Shuchi, Cooper, Matthew, DeHelian, Daniel, Zhao, Xuefei, Naik, Meghna U., Wurtzel, Jeremy G. T., Stalker, Timothy J., Goldfinger, Lawrence E., Benovic, Jeffrey, Brass, Lawrence F., McKenzie, Steven E., Naik, Ulhas P., Ma, Peisong
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2020
Sujets:
Thrombosis and Hemostasis
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6960467/
https://ncbi.nlm.nih.gov/pubmed/31899801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000467
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