RGS10 and RGS18 differentially limit platelet activation, promote platelet production, and prolong platelet survival

G protein–coupled receptors are critical mediators of platelet activation whose signaling can be modulated by members of the regulator of G protein signaling (RGS) family. The 2 most abundant RGS proteins in human and mouse platelets are RGS10 and RGS18. While each has been studied individually, cri...

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Bibliographische Detailangaben
Veröffentlicht in:Blood
Hauptverfasser: DeHelian, Daniel, Gupta, Shuchi, Wu, Jie, Thorsheim, Chelsea, Estevez, Brian, Cooper, Matthew, Litts, Kelly, Lee-Sundlov, Melissa M., Hoffmeister, Karin M., Poncz, Mortimer, Ma, Peisong, Brass, Lawrence F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2020
Schlagworte:
Thrombosis and Hemostasis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7544544/
https://ncbi.nlm.nih.gov/pubmed/32542378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019003251
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