GRK6 regulates the hemostatic response to injury through its rate-limiting effects on GPCR signaling in platelets

G protein–coupled receptors (GPCRs) mediate the majority of platelet activation in response to agonists. However, questions remain regarding the mechanisms that provide negative feedback toward activated GPCRs to limit platelet activation and thrombus formation. Here we provide the first evidence th...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Chen, Xi, Gupta, Shuchi, Cooper, Matthew, DeHelian, Daniel, Zhao, Xuefei, Naik, Meghna U., Wurtzel, Jeremy G. T., Stalker, Timothy J., Goldfinger, Lawrence E., Benovic, Jeffrey, Brass, Lawrence F., McKenzie, Steven E., Naik, Ulhas P., Ma, Peisong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6960467/
https://ncbi.nlm.nih.gov/pubmed/31899801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000467
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