GRK6 regulates the hemostatic response to injury through its rate-limiting effects on GPCR signaling in platelets

G protein–coupled receptors (GPCRs) mediate the majority of platelet activation in response to agonists. However, questions remain regarding the mechanisms that provide negative feedback toward activated GPCRs to limit platelet activation and thrombus formation. Here we provide the first evidence th...

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Dades bibliogràfiques
Publicat a:Blood Adv
Autors principals: Chen, Xi, Gupta, Shuchi, Cooper, Matthew, DeHelian, Daniel, Zhao, Xuefei, Naik, Meghna U., Wurtzel, Jeremy G. T., Stalker, Timothy J., Goldfinger, Lawrence E., Benovic, Jeffrey, Brass, Lawrence F., McKenzie, Steven E., Naik, Ulhas P., Ma, Peisong
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2020
Matèries:
Thrombosis and Hemostasis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6960467/
https://ncbi.nlm.nih.gov/pubmed/31899801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2019000467
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