Structure activity relationships of benzyl C-region analogs of 2-(3-fluoro-4-methylsulfonamidophenyl)propanamides as potent TRPV1 antagonists

A series of 2-substituted 4-(trifluoromethyl)benzyl C-region analogs of 2-(3-fluoro-4-methylsulfonamidophenyl)propanamides were investigated for hTRPV1 antagonism. The analysis indicated that the phenyl C-region derivatives exhibited better antagonism than those of the corresponding pyridine surroga...

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Pubblicato in:Bioorg Med Chem
Autori principali: Ann, Jihyae, Jung, Aeran, Kim, Mi-Yeon, Kim, Hyuk-Min, Ryu, HyungChul, Kim, Sunjoo, Kang, Dong Wook, Hong, Sunhye, Cui, Minghua, Choi, Sun, Blumberg, Peter M., Frank-Foltyn, Robert, Bahrenberg, Gregor, Stockhausen, Hannelore, Christoph, Thomas, Lee, Jeewoo
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6959537/
https://ncbi.nlm.nih.gov/pubmed/26474664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2015.10.001
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